Treatment Comparison for Clinically Localized Primary Prostate Cancer Therapies
|HIFU - (high intensity focused ultrasound)
||Minimally invasive use of focused ultrasound waves
to ablate diseased tissue
Incontinence: 0-10% 1-3
Impotence: 8-50% 4,5
Rectal Injury: <3% 4-6
|Catheter worn for
approximately 2-3 weeks; can
return to normal activities
within a few days
disease-free survival rate at 5 years; 55-98% negative biopsy 1-9
controlled freeze and thaw cycles to destroy the prostate
Incontinence: 3-10% 10
Impotence: 40-100% 10
Rectal Injury: 0-3% 10
|2-3 hour procedure with possible overnight stay; return to normal activities within a few days
disease-free survival at 5 years; 87-98% negative biopsy 11,12
||Surgery to remove
prostate, open or
Incontinence: 9-20% 13
Impotence: 4-85% 13
Rectal Injury:0-5% 14
|2-3 day hospital stay, catheter for 2-3 weeks for open surgery; shorter
hospitalization and fewer postoperative complications for laparoscopic procedure
disease-free survival 15,16
|External Beam Radiation
||6-8 week treatment;
beams to the prostate
Incontinence: 4-15% 17
Impotence: 41-62% 17
Rectal Injury: 15% 17
|Five treatments per week for 6-8 weeks, up to 2 months fatigue after full course of treatment
disease-free survival 18-19
||Minimally invasive implants of radiation seeds in the prostate
Incontinence: 3-18% 20
Impotence: 14-82% 20
Rectal Injury: 3% 21
|1-2 hour procedure with
possible overnight stay
disease-free survival 22
Data presented are for clinically localized, low-high risk primary prostate cancer. The information provided in the chart is therapy and not device specific and may not include all potential risks, recovery and outcome information. For further information please see references.
The Sonablate® 500 is approved for investigational use within the U.S. and is being studied for the treatment of prostate cancer in clinical trials in the U.S. The FDA has made no decision as to the safety or efficacy of the Sonablate® 500 for the treatment of prostate cancer. Currently, the device is available for the treatment of prostate cancer outside the U.S. in more than 30 countries.
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- Uchida T, Ohkusa H, Yamashita H, et al. Five years experience of transrectal high-intensity focused ultrasound using the Sonablate device in the treatment of localized prostate cancer. International journal of urology : official journal of the Japanese Urological Association 2006;13:228-33.
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